E

Definition: (noun) the illegal drug MDMA, also known as Ecstasy
Example: The reason Max scored an F on the test was that he had scored too much E the night before.
Quote:
“But now days these lil’ younguns rollin’ on E.”
- Rapper Ja Rule on the song Emerica
Like Cher or Madonna, this popular club drug doesn’t need more of a name to be recognized. In fact, the dangerous stimulant is so well known that it has two one-letter nicknames: E and X.
This is probably just as well, since its real name, methylenedioxymethamphetamine, is difficult to say—perhaps more so if you have been using it for a while. Ecstasy has been shown to cause memory and intelligence loss, among other unpleasant side effects.